Tesi: Epilessia, dieta e microbioma

Per rimanere sull’onda delle tesi, in allegato la mia tesi riguardo il rapporto fra epilessia, microbioma e dieta. Purtroppo per voi.. in inglese a “causa” della gentile revisione del Prof. Jan Suchodolski.

Eh si, sono scomparsa per un periodo bello lungo. Fra il lavoro clinico e la stesura della tesi in effetti diciamo che non ho avuto tempo per molto altro. Per questo sono contenta di condividere i miei sforzi, pubblicando online la mia Tesi per il Master di secondo livello in Nutrizione, Alimentazione e Dietetica Clinica del cane e del gatto, discussa il 2 febbraio 2018 presso l’Università degli Studi di Teramo. Relatore? Niente di meno che il prof. Jan Suchodolski dell’Università del Texas!

In particolare troverete approfondito:

  1. Epilessia idiopatica: dalla genetica alla epigenetica
  2. Dieta chetogenica
  3. Asse intestino – microbioma -cervello
  4. Dieta con acidi grassi a media catena (MCT)
  5. Utilizzo degli Omega-3 come integrazione funzionale durante patologie neurologiche

Per chi conosce l’inglese, buona lettura: potete scaricare la tesi cliccando qui. Per chi invece preferisce “giocare facile”, qui il link per l’articolo riguardo alimentazione e epilessia.

Cito dall’introduzione:

Epilepsy is one of the most common neurological disorders in dogs as well as in human beings. Although some cases recognize a specific etiopathogenesis, most cases are actually classified as “idiopathic”. Novel therapeutic approaches are needed since traditional drug therapeutic options may fail to treat seizures in dogs as well as in humans (Martle, Van Ham et al. 2014). Poor owners’ perception of their best friends’ quality of life may also be a good reason to challenge canine idiopathic epilepsy from a new point of view (Wessmann, Volk et al. 2016).

Recent research showed how deeply gut microbiota and the brain interact with each other (Wang and Wang 2016). A bidirectional communication between the central and enteric nervous systems, together with an important role played by gut microbiota, has led to the term “Gut-Microbiota-Brain Axis” (Wang and Wang 2016). It is nowadays believed that, in addition to influencing digestive system function, symbiotic microbiota can bidirectionally and reversibly impact various extra-intestinal pathogenic processes, including those of the nervous system and behavior (Packer, Law et al. 2016, Wu, Zhang et al. 2016). Some studies suggest how gut microbiota may be an alternative therapeutic target for epilepsy in humans, via diet of pharmacological modulation (Wu, Zhang et al. 2016).

Nevertheless, while in human Medicine a clear correlation between at least some cases of idiopathic epilepsy and diet is already well established (Sampaio 2016), in Veterinary Medicine we still have no final data on it (Larsen, Owens et al. 2014, Podell, Volk et al. 2016).

This thesis has been written with the purpose of going deeper into the subject of epilepsy – microbiota – diet correlation, comparing, at the best of the Author’s knowledge, existing data in both human and veterinary medicine as a base for future clinical trial on canine patients.

Bibliografia: nella tesi

 

 

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